| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1251393 | Chemical Research in Chinese Universities | 2006 | 7 Pages |
Abstract
A series of ethyl 5-hydroxyindole-3-carboxylates 6a-10r was designed and synthesized. The structures of all the compounds were confirmed by IR, 1H NMR, and MS and their anti-hepatitis B virus (HBV) activities were evaluated in 2. 2. 15 cells. Among them, compound 7g {ethyl 5-hydroxy-2-[(3-methoxyphenylsulfinyl) methyl]-1-methyl-4-[(4-methylpiperazin-1-yl)methyl]-1H-indole-3-carboxylate} displays a significant anti-HBV activity, which is more potent than the positive control lamivudine.
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Authors
ZHAO Chun-shen, ZHAO Yan-fang, CHAI Hui-fang, GONG Ping,