Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1251542 | Chemistry and Physics of Lipids | 2016 | 14 Pages |
Abstract
Whereas asymmetric transbilayer lipid distribution in the plasma membrane is well recognized, methods to examine the precise localization of lipids are limited. In this review, we critically evaluate the methods that are applied to study transbilayer asymmetry of lipids, summarizing the factors that influence the measurement. Although none of the present methods is perfect, the current application of immunoelectron microscopy-based technique provides a new picture of lipid asymmetry. Next, we summarize the transbilayer distribution of individual lipid in both erythrocytes and nucleated cells. Finally we discuss the concept of the interbilayer communication of lipids.
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Motohide Murate, Toshihide Kobayashi,