Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1251678 | Chemistry and Physics of Lipids | 2015 | 16 Pages |
Abstract
The genus Pseudomonas is one of the most heterogeneous groups of eubacteria, presents in all major natural environments and in wide range of associations with plants and animals. The wide distribution of these bacteria is due to the use of specific mechanisms to adapt to environmental modifications. Generally, bacterial adaptation is only considered under the aspect of genes and protein expression, but lipids also play a pivotal role in bacterial functioning and homeostasis. This review resumes the mechanisms and regulations of pseudomonal glycerophospholipid synthesis, and the roles of glycerophospholipids in bacterial metabolism and homeostasis. Recently discovered specific pathways of P. aeruginosa lipid synthesis indicate the lineage dependent mechanisms of fatty acids homeostasis. Pseudomonas glycerophospholipids ensure structure functions and play important roles in bacterial adaptation to environmental modifications. The lipidome of Pseudomonas contains a typical eukaryotic glycerophospholipid - phosphatidylcholine -, which is involved in bacteria-host interactions. The ability of Pseudomonas to exploit eukaryotic lipids shows specific and original strategies developed by these microorganisms to succeed in their infectious process. All compiled data provide the demonstration of the importance of studying the Pseudomonas lipidome to inhibit the infectious potential of these highly versatile germs.
Keywords
LPST6SST3SSHPTLCMSICDPPLDLPAPGPACPAHLFASPI(3,4,5)P3PI(4,5)P2phosphatidic acidlysophosphatidic acidInteractionsBiosynthesismass spectrometry imagingLineagecytidine diphosphateHead groupFatty acid synthesistype 3 secretion systemMembranesOuter membraneinner membranephosphatidylcholinephosphatidylglycerolphosphatidylglycerol phosphatephosphatidylethanolaminePhosphatidylserinePhosphatidylinositol phosphatephosphatidylinositol 3,4,5-trisphosphatephosphatidylinositol 4,5-biphosphatePhosphoinositidePhospholipase DPhospholipidsN-acyl homoserine lactonelipopolysaccharideLipidomicsHostacyl carrier proteinPiPCardiolipinHigh performance thin-layer chromatographyglycerophospholipid
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Tatiana Kondakova, François D'Heygère, Marc J. Feuilloley, Nicole Orange, Hermann J. Heipieper, Cécile Duclairoir Poc,