| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1251858 | Chemistry and Physics of Lipids | 2013 | 7 Pages |
•The effect of amino acids on physicochemical parameters of the phosphatidylcholine membranes.•Determination of surface area of phosphatidylcholine–amino acid domains.•Application of electrochemical impedance spectroscopy to the research of lipid bilayers.
Bilayer lipid membranes composed of phosphatidylcholine and isoleucine or phosphatidylcholine and tyrosine were investigated using electrochemical impedance spectroscopy. Interaction between membrane components causes significant deviations from the additivity rule which can be explained by formation of the domain structures. The surface area of domains was calculated based on derived equations. We suggest that the stoichiometry of phosphatidylcholine–isoleucine domain is equal 3:1. In the case of tyrosine-modified phosphatidylcholine membranes, domain with stoichiometry 7:1 should be taken into consideration.
