| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1251917 | Chemistry and Physics of Lipids | 2011 | 8 Pages |
Abstract
⺠NSAIDs promoted distinct inhibitory effects of PLA2. ⺠Meloxicam, nimesulide and lornoxicam inhibit PLA2 by shielding the Trp residues and reducing PLA2 flexibility, both mechanisms concurring for the enzyme inhibition. ⺠Tenoxicam does not reduce PLA2 flexibility, but shields Trp residues that become less available to take part in the enzyme interfacial activation.
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Authors
Diana Gaspar, Marlene Lúcio, Sandra Rocha, J.L.F. Costa Lima, Salette Reis,