| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1251948 | Chemistry and Physics of Lipids | 2012 | 9 Pages |
Abstract
⺠The 3-sulfates of glutathione conjugated bile acids (BA-GSH) were synthesized. ⺠The properties of the BA-GSH 3-sulfates were characterized by negative-ion ESI-MS/MS. ⺠The sulfation of BA-GSH was determined by monitoring characteristic transition ions. ⺠A little sulfation of the BA-GSH occurred at C-3 in a rat liver cytosolic fraction. ⺠Sulfation was proportional to the hydrophobicity of the unconjugated bile acids.
Keywords
DCACOACDCAESINACCIDSRMUDCAGSH1H NMR3′-phosphoadenosine 5′-phosphosulfateBAsN-acetylcysteinePAPsCollision-induced dissociationLCAinternal standardChenodeoxycholic acidDeoxycholic acidLithocholic acidCholic acidBile acidsUrsodeoxycholic acidMass spectrometryReversed-phaseselected reaction monitoringliquid chromatographyhigh-performance liquid chromatographyHPLCcoenzyme AGlutathioneelectrospray ionization
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Kuniko Mitamura, Naohiro Hori, Shiori Mino, Takashi Iida, Alan F. Hofmann, Shigeo Ikegawa,