| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1252139 | Chemistry and Physics of Lipids | 2010 | 7 Pages |
Abstract
A series of new phosphatidylcholine analogues with structurally modified sn-2-substituents have been prepared. The synthetic compounds include oligo(ethylene glycol) derivatives with chain-terminal pharmacophores that upon catalytic hydrolysis by phospholipase A2 yielded a series of oligo(ethylene glycol)-conjugates of the respective drugs. The approach here outlined may open a new way to employ OEG derivatives of phospholipids for therapeutic applications as secretory PLA2-targeted precursors of prodrugs.
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Authors
Renato Rosseto, Joseph Hajdu,