Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1252475 | Chemistry and Physics of Lipids | 2008 | 11 Pages |
For drug delivery purpose the anticancer drug S12363 was loaded into ESM/Chol–liposomes using either a pH or an ammonium gradient. Association between the drug and the liposome depends markedly on the liposome membrane structure. Thus, ESM and ESM/Chol bilayer organization had been characterized by coupled DSC and XRDT as a function of both cholesterol concentration and aqueous medium composition. ESM bilayers exhibited a ripple lamellar gel phase Pβ′ below the melting temperature and adopted a Lβ-like gel phase upon Chol insertion. Supramolecular organization of ESM and ESM/Chol bilayers was not modified by citrate buffer or ammonium sulfate solution whatever the pH (3 ≤ pH ≤ 7). Nevertheless, in ESM bilayer, ammonium sulfate salt induced a peculiar organization of head groups, leading to irregular d-spacing and weakly correlated bilayers. Moreover, in the presence of salts, a weakening of van der Waals attraction forces was seen and led to a swelling of the water layer.