| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1252815 | Arabian Journal of Chemistry | 2014 | 6 Pages |
Abstract
The methanol leaf extract of Mallotus oppositifolius was evaluated for anti-inflammatory activity in rats and mice using acute and chronic anti-inflammatory models with acetylsalicylate acid (aspirin) as the reference drug. The antioxidant activity was done in vitro using ferric reducing antioxidant power (FRAP) and 1,1-diphenyl-2-hydrazyl (DPPH) spectrophotometric assays. The extract dose dependently and significantly reduced paw edema volume in rats induced by carrageenan (p < 0.01), decreased croton oil-induced ear inflammation (p < 0.05), inhibited cotton pellet-induced granuloma in mice and reduced the rat paw thickness in formalin-induced arthritis.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Chinaka O. Nwaehujor, Maxwell I. Ezeja, Nkeiruka E. Udeh, Dozie N. Okoye, Rita I. Udegbunam,