| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1252847 | Arabian Journal of Chemistry | 2014 | 5 Pages |
An HPTLC method for analysis of Exemestane in bulk and pharmaceutical formulation has been established and validated. The analyte was separated on aluminium plates precoated with silica gel 60 F254. The mobile phase was chloroform:methanol 9.2:0.8 (v/v). Quantification was done by densitometric scanning at 247 nm. Response was a linear function of Exemestane concentration in the range of 100–500 μg mL−1. The limit of detection and quantification for Exemestane were 5.8 and 17.58 μg mL−1, respectively. Average recovery of Exemestane was 100.1, which shows that the method was free from interference from excipients present in the formulation. The established method enabled accurate, precise, and rapid analysis of Exemestane in bulk as well as pharmaceutical formulation.
