Synthesis, Characterization and Cytotoxicity of Ammine/Methylamine Platinum (II) Complexes with Carboxylates

Seven novel platinum (II) complexes [Pt (II) (NH3) (CH3NH2) X2] (I-VII) (X: CH3COO−, CH2ClCOO−, CHCl2COO−, C6H5COO−, p-CH3 OC6 H4COO−, p-NH2C6H4COO−, p-NO2C6H4COO−) were prepared and characterized by means of elemental analysis, molar conductivity, thermal analysis, IR, UV, and 1H NMR spectrometries. The cytotoxicity against HCT-8, BGC-823, MCF-7, EJ, and HL-60 cell lines increases in the following sequence: cisplatin > IV > V > VI > VII > I > II > III. Moreover, the complexes (I - VII) display substantially greater activities against EJ and HL-60 cell lines than those against the cell lines from other carcinomas. They can induce a concentration-dependent accumulation of HL-60 cells in the G2/M phase of the cell cycle as cisplatin. There is no significant correlation between total DNA platination levels and cytotoxicity of the complexes.