Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1253212 | Chemical Research in Chinese Universities | 2008 | 5 Pages |
Abstract
Ursolic acid was modified at C3 and C28 position to obtain fourteen derivatives including twelve novel compounds, and their chemical structures were characterized by IR, 1H NMR and MS. Cell growth inhibitory effects of the derivatives against Hela cell were evaluated by MTT assay. All these derivatives were found to have stronger cell growth inhibitory than their parent compound, ursolic acid. The derivatives with a substituted acetyl group at C3 hydroxyl group show better activities than those with an unsubstituted hydroxyl group.
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Authors
Dan LIU, Yan-qiu MENG, Juan ZHAO, Li-gong CHEN,