Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1253213 | Chemical Research in Chinese Universities | 2008 | 7 Pages |
Abstract
A series of novel alkylthio/sulfinyl-8H-thieno[2,3-b]pyrrolizin-8-oximino derivatives V1-VIII15 were designed and synthesized as antitumor agents. Their structures were confirmed using IR, 1H NMR, elemental analysis, and MS. The antitumor activities of all the target compounds were tested by the MTT method in vitro against Bel-7402, HT-1080, SGC-7901, and A549 Cell Lines. Among them, compound VI9 displayed a promising antitumor activity superior to that of Cisplatin.
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Chemistry
Chemistry (General)
Authors
Shu-chun GUO, Yan-fang ZHAO, Rong-dong LI, Li-jun XIE, You-bin YANG, Ping GONG,