Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1253221 | Chemical Research in Chinese Universities | 2008 | 4 Pages |
Abstract
In the present study, we identified the natural compound curcumin to be an effective G551D-CFTR activator by cell-based fluorescent assay and electrophysiological measurement. We demonstrated that curcumin can restore the impaired chloride conductance of G551D mutant CFTR. The activity is rapid, reversible, and cAMP-dependent. Our study identified a new natural lead compound for the pharmacological therapy of cystic fibrosis caused by G551D mutation of CFTR.
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Authors
Li-ming HAO, Xin LIU, Li-na XU, Na ZHU, Sen LIN, Shu-guang HOU, Na ZHOU, De-cheng SHI, De-jing SHANG, Tong-hui MA, Hong YANG,