Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1253246 | Chemical Research in Chinese Universities | 2007 | 4 Pages |
Abstract
Two novel compounds(4a and 4b) were obtained by the association of 2, 2, 4-trimethyl-3-hydroxy-5-cyclohexenecarboxylate with (S)-isoserine derivatives. The space location of the hydroxyl group of compound 1 was identified via the formation of lactone 6. Fe2(SO4)3 · ÏH2O was used as the catalyst for the synthesis of lactone 6. The carboxyl group was selectively protected with diazomethane. All the products were characterized via1H NMR and mass spectra. The Docking study showed that the associations have the potential therapeutic use of DPP-IV inhibitor.
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Chemistry
Chemistry (General)
Authors
WANG Lei, ZHENG Qing-chuan, SONG Zhi-guang, FANG Wei-shuo, LI Ye-zhi, HUANG Hua-min,