Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1253247 | Chemical Research in Chinese Universities | 2007 | 9 Pages |
Abstract
A series of succinate-derived macrocyclic amides(1) was synthesized via ring-closing metathesis(RCM) as the key step. The substrate included 12 to 15 members. The metathesis precursors were obtained from the amide coupling of tert-butyl 3-carboxyhex-5-enoate(2) with numerous side-chain alkenylated amino acid esters of general type(3) derived from L-lysine and L-ornithine.
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Chemistry (General)
Authors
ZHAO Bao-xiang, SCHAUDT Marco, BLECHERT Siegfried,