| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1256605 | Current Opinion in Chemical Biology | 2011 | 8 Pages |
Abstract
Natural products are evolutionarily designed and chemically distinct from most synthetic library molecules. In addition to their role as drugs, they are successfully used as molecular probes to identify disease relevant targets. Novel natural products are still routinely discovered from traditional sources through cultivation of microorganisms. Complementary approaches based on genome sequence information and subsequent annotation of biosynthetic pathways are emerging technologies. However, to be of practical use for drug discovery, these concepts must be advanced beyond their current state.
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Esther K Schmitt, Charles M Moore, Philipp Krastel, Frank Petersen,