| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1256721 | Current Opinion in Chemical Biology | 2010 | 7 Pages |
Abstract
Some therapeutic monoclonal antibodies function by focusing the killing power of the immune system on particular cellular targets, a process known as antibody-dependent cell-mediated cytotoxicity (ADCC). There is considerable interest in developing small-molecule therapeutics that utilize this mechanism of action and so act as a kind of antibody surrogate. Progress and challenges in this interesting field are reviewed here.
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Chemistry (General)
Authors
Thomas Kodadek,