Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1256832 | Current Opinion in Chemical Biology | 2010 | 15 Pages |
Abstract
This review explores the concept of using privileged scaffolds to identify biologically active compounds through building chemical libraries. We hope to accomplish three main objectives: to provide one of the most comprehensive listings of privileged scaffolds; to reveal through four selected examples the present state of the art in privileged scaffold library synthesis (in hopes of inspiring new and even more creative approaches); and also to offer some thoughts on how new privileged scaffolds might be identified and exploited.
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Matthew E Welsch, Scott A Snyder, Brent R Stockwell,