| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1257051 | Current Opinion in Chemical Biology | 2007 | 6 Pages |
Abstract
Flexizymes are de novo ribozymes capable of charging a wide variety of non-natural amino acids on tRNAs. The flexizyme system enables reprogramming of the genetic code by reassigning the codons that are generally assigned to natural amino acids to non-natural residues, and thus mRNA-directed synthesis of non-natural polypeptides can be achieved. In this review, we comprehensively summarize the history of the flexizyme system and its subsequent development into a practical tool. Furthermore, applications to the synthesis of novel biopolymers via genetic code reprogramming and perspectives for future applications are described.
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Chemistry (General)
Authors
Masaki Ohuchi, Hiroshi Murakami, Hiroaki Suga,