| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1257054 | Current Opinion in Chemical Biology | 2007 | 8 Pages |
Abstract
The recent discovery that histone demethylation can be catalyzed by the flavin-dependent amine oxidase LSD1 has ushered in a new chapter in the chromatin-remodeling community. Herein, we discuss the rapid progress of the histone demethylase field including the recent identification of the non-heme iron-dependent histone demethylases (JmjC family), the basis for LSD1 substrate site specificity and the newly emerging potential for inhibition of these enzymes in structural and functional analysis.
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Jeffrey C Culhane, Philip A Cole,