| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1257823 | Current Opinion in Chemical Biology | 2006 | 6 Pages |
Abstract
Elastin-like polypeptides (ELPs) are artificial polypeptides, derived from Val-Pro-Gly-Xaa-Gly (VPGXG) pentapeptide repeats found in human tropoelastin, that reversibly coacervate above a critical temperature. Genetically encodable ELPs are monodisperse, stimuli responsive, and biocompatible, properties that make them attractive for drug delivery and tissue engineering. The potential of ELPs to self-assemble into nanostructures in response to environmental triggers is another interesting feature of these polypeptides that promises to lead to a host of new applications.
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Authors
Ashutosh Chilkoti, Trine Christensen, J Andrew MacKay,