Lanthanide amino acid Schiff base complexes: synthesis, spectroscopic characterization, physical properties and in vitro antimicrobial studies

Complexes of La (III), Nd(III), Gd(III), Sm(III), and Ce(IV) were synthesized with Schiff base [(3,5-di-tert-butyl-2-hydroxybenzyl) amino] acetic acid (H3L). The ligand and its complexes were synthesized and characterized based on the following analysis: elemental analyses, FAB-mass, molar conductance measurements, magnetic measurement, UV-visible, IR, and NMR spectral studies. The spectral data revealed that the ligand acted as a neutral tridentate coordinating to metal ion through ONO donor sequence. Thermal degradation studies of the ligand and its complexes showed that the previous lanthanide complexes were more thermally stable than the ligand itself. The Schiff base and its complexes were screened for their antibacterial (Escherichia coli, Staphylococcus aureus) and antifungal (Aspergillus flavus and Candida Albicans).

Graphical abstractSuggested structures of the ligand and its metal complexesFigure optionsDownload full-size imageDownload as PowerPoint slide