Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1259367 | Current Opinion in Chemical Biology | 2009 | 6 Pages |
Abstract
Recent advances in single-cell assays have focused attention on the fact that even members of a genetically identical group of cells or organisms in identical environments can exhibit variability in drug sensitivity, cellular response, and phenotype. Underlying much of this variability is stochasticity in gene expression, which can produce unique proteomes even in genetically identical cells. Here we discuss the consequences of non-genetic cell-to-cell variability in the cellular response to drugs and its potential impact for the treatment of human disease.
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Mario Niepel, Sabrina L Spencer, Peter K Sorger,