| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1259459 | Current Opinion in Chemical Biology | 2008 | 11 Pages |
Abstract
Several years ago small molecular weight protein–protein interaction (PPI) antagonists were considered as the Mount Everest in drug discovery and generally regarded as too difficult to be targeted. However, recent industrial and academic research has produced a great number of new antagonists of diverse PPIs. This review structurally analyses small molecular weight PPI antagonists and their particular targets as well as tools to discover such compounds. Besides general discussions there will be a focus on the PPI p53/mdm2.
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Alexander Dömling,