| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1259460 | Current Opinion in Chemical Biology | 2008 | 5 Pages |
Abstract
The demand for modified peptides with improved stability profiles and pharmacokinetic properties is driving extensive research effort in this field. Many structural modifications of peptides guided by rational design and molecular modeling have been established to develop novel synthetic approaches. Recent advances in the synthesis of conformationally restricted building blocks and peptide bond isosteres are discussed.
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Josef Vagner, Hongchang Qu, Victor J Hruby,