| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1259463 | Current Opinion in Chemical Biology | 2008 | 6 Pages |
Abstract
A further refinement of the concept of drug-likeness is required for compound libraries intended for central nervous system (CNS) targets to account for the limitations imposed by blood–brain barrier permeability. This review describes criteria and processes that can be applied in the de novo design and assembly of libraries to increase the odds of compounds residing within CNS-accessible chemical space. A number of published examples where CNS activity and/or penetration characteristics have been a factor in library design are discussed.
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Stephen A Hitchcock,