Synthesis, characterization and preliminary in vitro antibacterial screening activity of metal complex derivatives of 2-[(5-styryl-[1,3,4]thiadiazol-2-ylimino)-methyl]-phenol

Five new metal complex derivatives of 2-[(5-styryl-[1,3,4]thiadiazol-2-ylimino)-methyl]-phenol with the metal ions [Ni(II), Cu(II), Zn(II), Cd(II) and Sn(II)] were prepared in alcoholic medium. The complexes were characterized quantitatively and qualitatively by micro elemental analysis, Fourier transform infrared spectroscopy, ultraviolet–visible spectroscopy, mass spectroscopy, 1H and 13C nuclear magnetic resonance, magnetic susceptibility and conductivity measurements. The spectral study showed that all the complexes obtained as monomeric structures and the central metal moieties are four-coordinated, with tetrahedral geometry, except for the Cu(II) complex, which had square planar geometry. In preliminary in vitro antibacterial screening, all the complexes showed moderate activity against the bacterial strains tested, which was slightly higher than with the ligand.