Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1265452 | Ultrasonics Sonochemistry | 2012 | 6 Pages |
Abstract
A facile, efficient and environment-friendly protocol for the synthesis of 6-chloro-5-formyl-1,4-dihydropyridine derivatives has been developed by the convenient ultrasound-mediated reaction of 2(1H)pyridone derivatives with the Vilsmeier–Haack reagent. This method provides several advantages over current reaction methodologies including a simpler work-up procedure, shorter reaction times and higher yields.
► Ultrasonic-assisted synthesis of 6-chloro-5-formyl-1,4-dihydropyridine derivatives. ► The ultrasound irradiation accelerates the reaction rate greatly under mild conditions. ► Better reaction times than conventional methods.
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Enrique Ruiz, Hortensia Rodríguez, Julieta Coro, Vladimir Niebla, Alfredo Rodríguez, Roberto Martínez-Alvarez, Hector Novoa de Armas, Margarita Suárez, Nazario Martín,