| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1265459 | Ultrasonics Sonochemistry | 2012 | 6 Pages |
A facile and efficient one-pot three-component procedure for synthesis of novel dispirooxindolecyclo[pyrrolo[1,2-c]thiazole-6,5′-thiazolidine] derivatives without any catalysts under ultrasonic condition has been developed. Combining with the advantages of sonochemistry, such as mild reaction conditions, good yield and short reaction times, we have made a progress on construction of novel disiproheterocyclic compounds via the 1,3-dipolar cycloaddition of azomethine ylides. Several experiments were especially carried out for investigating the acceleration mechanism of ultrasound on the cycloaddition.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Ultrasonic-assisted synthesis of novel dispiroheterocyclic compounds. ► Ultrasonic irradiation was found to have beneficial effect on the synthesis. ► The effect of frequency and temperature of ultrasound irradiation on the reaction was studied. ► The role and acceleration mechanism of sonication in the present system was discussed. ► Mechanistic study of ultrasonic-assisted synthesis of novel dispiroheterocycle compounds.
