| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1265781 | Ultrasonics Sonochemistry | 2016 | 9 Pages |
•HIFU induced PEG-click-PPG copolymer micelle structure change was studied.•HIFU induced site-specific degradation mechanism was further confirmed.•The multiple ester bonds rather than the 1, 2, 3-triazole ring were cleaved under HIFU.
The well-defined amphiphilic poly(ethylene glycol)-block-poly(propylene glycol) copolymer containing 1, 2, 3-triazole moiety and multiple ester bonds (PEG-click-PPG) was prepared by click reaction strategy. The PEG-click-PPG copolymer can self-assemble into spherical micelles in aqueous solution. It is found that high intensity focused ultrasound (HIFU) can open the copolymer PEG-click-PPG micelles and trigger the release of the payload in the micelle. The multiple ester bonds introduced in the junction point of the copolymer chain through click reactions were cleaved under HIFU, and leads to the disruption of the copolymer micelle and fast release of loaded cargo. The click reaction provides a convenient way to construct ultrasound responsive copolymer micelles with weak bonds.
