| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1265917 | Ultrasonics Sonochemistry | 2009 | 4 Pages |
Abstract
A new, fast, efficient and general method for preparation of steroid analogous of anticipated biological activity under ultrasound irradiation and classical heating is reported. The reaction pathway involves two steps: quaternization of phthalazine heterocycle followed by a 3+2 dipolar cycloaddition of cycloimmonium ylides to dienophiles. Under ultrasound the reaction time decreases substantially, the yields are higher, the reaction conditions are milder. A comparative study ultrasound verses classical heating has been done.
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Authors
Vasilichia Bejan, Costel Moldoveanu, Ionel I. Mangalagiu,