Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1265969 | Ultrasonics Sonochemistry | 2015 | 6 Pages |
Abstract
Lactic acid has been used as a bio-based green solvent to study the ultrasound-assisted scale-up synthesis. We report here, for the first time, on the novel and scalable process for synthesis of pyrrole derivatives in lactic acid solvent under ultrasonic radiation. Eighteen pyrrole derivatives have been synthesized in lactic acid solvent under ultrasonic radiation and characterized by 1H NMR, IR, ESI MS. The results show, under ultrasonic radiation, lactic acid solvent can overcome the scale-up challenges and exhibited many advantages, such as bio-based origin, shorter reaction time, lower volatility, higher yields, and ease of isolating the products.
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Shi-Fan Wang, Chao-Lun Guo, Ke-ke Cui, Yan-Ting Zhu, Jun-Xiong Ding, Xin-Yue Zou, Yi-Hang Li,