Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1266360 | Ultrasonics Sonochemistry | 2011 | 4 Pages |
Abstract
Carboxylic acids are promising candidates for new sustainable strategies in organic synthesis. In this paper, we ascertain the potential of ultrasound for the hydrolysis of nitriles into carboxylic acids through the study of key parameters of the reaction: pH, hydrolysis medium, reaction time and activation technique. The positive influence of ultrasound under basic conditions is due to more than mechanical effects of cavitation. Indeed, the rate of hydrolysis is dramatically increased under sonication in NaOH solutions. A radical mechanism involving the oxide anion radical O− is proposed.
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Pascal Lignier, Julien Estager, Nathalie Kardos, Lydie Gravouil, Julien Gazza, Emmanuel Naffrechoux, Micheline Draye,