A one-pot three-component synthesis of 4,6-diarylpyrimidin-2(1H)-ones (DAPMs) using atomized sodium in THF under sonic condition

•This one-pot route is mild and inexpensive.•Reaction goes to completion in very short time with high yields.•The use of small amount (2.0 mg atom) of catalyst.•The catalyst is cheap, easy to handle and commercially available.•The reactions are energy efficient and involve use of a green technique.

A simple and an efficient procedure for the synthesis of 4,6-diarylpyrimidin-2(1H)-ones using atomized sodium/THF via a one-pot three-component Biginelli-like cyclocondensation of an aldehyde, a methyl ketone and urea under ultrasonic condition is developed. The method is mild and inexpensive; yields are high and the reactions go to completion within 10–15 min.