| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1269094 | Ultrasonics Sonochemistry | 2013 | 5 Pages |
A one-pot three-component condensation of an aldehyde, 2-naphthylamine, and acetamide has been achieved by sonication at 35 kHz. The reaction is catalysed by silica chloride in aqueous medium. This protocol afforded corresponding 1-amidoalkyl-2-naphthylamines in shorter reaction durations, and in high yields. The method involves simple work-up procedure, and avoids use of hazardous reagents.
► Development of new energy efficient synthetic methodology for γ-aminoamides. ► An efficient use of silica chloride as heterogeneous catalysts. ► Use of universal solvent–water as a reaction medium. ► One-pot multi-component synthesis of novel amidoalkyl-2-naphthylamines. ► Use of alternate source of energy-ultrasound in the synthesis of substituted amides.
