The copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) “click” reaction and its applications. An overview

A short overview of the copper(I)-catalyzed azide alkyne cycloaddition (CuAAC), the most used “click” reaction, is presented, including the introduction of the “click” concept, the conditions of copper(I) catalysis, the regioselectivity, the nature of the catalysts and ligands, mechanistic features, experimental conditions and applications to organic synthesis and organic materials.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (135 K)Download as PowerPoint slideHighlights► Overview of the copper-catalyzed alkyne-azide reaction. ► Main features and applications. ► Catalysts, ligands, substrates, solvents. ► Applications to organic, dendrimer and polymer synthesis.