Article ID Journal Published Year Pages File Type
1300503 Coordination Chemistry Reviews 2012 15 Pages PDF
Abstract

This review focuses on recent progress in organocatalytic and metal-mediated asymmetric [3 + 2] cycloadditions, including ‘click’ chemistry, asymmetric 1,3-dipolar and asymmetric non-1,3-dipolar [3 + 2] cycloadditions. The theoretical aspects and synthetic applications of these organocatalytic and metal-mediated asymmetric [3 + 2] cycloadditions are summarized. In addition, an understanding of the mechanistic details which lead to efficient stereoselectivity in organocatalytic and metal-mediated asymmetric [3 + 2] cycloadditions is provided. Most of the references reviewed in this paper are from 2007 upto now.

► 1,3-Dipolar reactions subject to both concerted reaction mechanism and the stepwise mechanism. ► Click chemistry is not a concerted 1,3-dipolar cycloaddition but a stepwise copper(I)-catalyzed process. ► Theoretical aspects and synthetic applications of these organocatalytic and metal-mediated asymmetric [3 + 2] cycloadditions are summarized. ► FMO theory to the reactivity of concerted 1,3-dipolar cycloadditions is reviewed.

Related Topics
Physical Sciences and Engineering Chemistry Inorganic Chemistry
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