Applications of 31P NMR spectroscopy in development of M(Duphos)-catalyzed asymmetric synthesis of P-stereogenic phosphines (M = Pt or Pd)

This perspective describes the use of 31P NMR spectroscopy in an ongoing research project on enantioselective P−C bond formation catalyzed by platinum and palladium Duphos complexes. This technique was used to characterize catalyst precursors, intermediates and products, to determine equilibrium and rate constants, and to measure the enantiomeric excess (ee) of the P-stereogenic phosphine products. Applications of 31P NMR spectroscopy in problem-solving and identifying unexpected products, as well as the analysis of an unusual and esthetically pleasing spectrum, are also discussed.