Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1301072 | Coordination Chemistry Reviews | 2012 | 11 Pages |
The potential therapeutic effects of carbon monoxide in several disease states, and new methodologies for CO delivery to specific targets is a topic of growing interest in mammalian physiology. Here we provide an overview of recent efforts in this laboratory regarding several types of carbonyl complexes of the group 6 metal and of those in other laboratories that are focused on developing photochemical techniques for such CO delivery. Photo-activated carbon monoxide releasing moieties (photoCORMs) based on manganese, iron and group 6 metals are described.
► We describe desired properties for photochemical CO delivery to biological targets. ► We also describe analytical challenges encountered in developing photoCORMs. ► We outline previous investigations of photoCORMs published by us and others. ► We present a new class of photoCORMs where CO is labilized by visible light.