Recent advances of discrete coordination complexes and coordination polymers in drug delivery

Article ID	Journal	Published Year	Pages	File Type
1301104	Coordination Chemistry Reviews	2011	19 Pages	PDF

Abstract

âº Lipophilicity of a coordination complex is predictable based on the logÂ P of the AL. âº MIL-101 shows remarkable drug loading capacity, 140% (w/w) of drug/carrier. âº CPs show exceptional performance over the adsorption-storage-delivery cycle for NO. âº In animal studies, no significant toxic effects were observed for MIL(Fe) NCPs. âº Anti-HIV activities of AZT-TP loaded NCPs were proven.

Keywords

MIL CuS API ESI-MS ASP ADMET GRAS SBF SAS DSCP PiB NMES NSAIDS MOPS XRPD SEDDS BIX Daunomycin FDA MCPS Nanoscale coordination polymers DDSs NCPs CPT PVP DLS BDC PBS cps DOX DFT MOFs DAU Electrospray Ionization Mass Spectrometry Terephthalic acid generally recognized as safe Drug delivery absorption, distribution, metabolism, excretion, and toxicity Nonsteroidal anti-inflammatory drugs Pharmaceutical SBU CNS Doxorubicin BCs Food and Drug Administration BBB Blood–brain barrier Supramolecular Self-emulsifying drug delivery system biopharmaceutics classification system central nervous system Drug delivery systems DOSY Metal-Organic Frameworks Ibuprofen LDH Ancillary ligand Ibu Simulated body fluid Phosphate-buffered saline SEM Active Pharmaceutical Ingredient scanning electron microscope Nanoscale Density functional theory New molecular entities Nitric oxide Coordination Layered double hydroxide Secondary building units Dynamic Light Scattering polyethylene glycol polyvinyl pyrrolidone Coordination polymers PEG camptothecin