Preparation and catalytically study of metal–organic frameworks of amine/MIL-53 (Al) as a powerful option in the rapid N-formylation condensation in neat conditions

•An efficient and waste-free approach for organic synthesis.•Amine/MIL-53 (Al) MOF that provide a synergistic means of a suitable mesochannels to drive out the products and water for next recycles.•Represents advantages, operational simplicity, higher yield and easy filterable workup.

This paper reports on the preparation and application of amine/MIL-53 (Al) as highly active catalysts for the N-formylation reaction. These Al-MOFs were found to be an efficient, selective and waste-free green solid catalyst for the net condensation of amines and formic acid. The catalyst can be isolated from the reaction mixture and reused at least 6 times.

Graphical abstractThe metal–organic frameworks of amine/MIL-53 (Al) was found to be an efficient, selective and waste-free green solid catalyst for the net condensation of amines and formic acid.Figure optionsDownload full-size imageDownload as PowerPoint slide