Preparation of diazenecarboxamide–carboplatin conjugates by click chemistry

An alternative, mild and highly efficient synthetic approach to platinum complexes with bioactive carrier ligands features a platinum-complex-tolerant copper(I)-catalyzed 1,3-dipolar cycloaddition. As demonstrated by the preparation of novel diazenecarboxamide–carboplatin conjugates, this approach is superior to other methodologies.

Graphical abstractAn alternative, mild and highly efficient synthetic approach to platinum complexes with bioactive carrier ligands features a platinum-complex-tolerant copper(I)-catalyzed 1,3-dipolar cycloaddition – click chemistry.Figure optionsDownload full-size imageDownload as PowerPoint slide