Multinuclear magnetic resonance studies of the reactions of the antitumor complexes cis-Pt(L)2X2 and cis-Pt(NH3)(L)X2 (LÂ =Â cyclobutylamine and cyclopentylamine) with guanosine and other bases and crystal structures of Pt(cyclopentylamine)2I2

The crystallographic structures of two different Pt(cyclopentylamine)2Cl2 crystals were found to be disordered. The first compound is the trans isomer, while the second crystal contains both isomers cis- and trans-Pt(cyclopentylamine)2Cl2. In the trans molecules the two amines are on the same side of the Pt(II) plane to maximize the H-bonds, while in the cis compound the two ligands are on opposite sides. The reactions of the antitumor complexes cis-Pt(amine)2X2 and cis-Pt(NH3)(amine)X2 (L = cyclobutylamine and cyclopentylamine) with guanosine and other bases were studied by multinuclear magnetic resonance spectroscopy.