Part XXIII. Synthesis and characterization of platinum(IV) complexes with O,O′-dialkyl esters of (S,S)-ethylenediamine-N,N′-di-2-(3-methyl)butanoic acid and bromido ligands. Antimicrobial, antibiofilm and antioxidant screening

•Four new platinum(IV) complexes with edda-type of ligand were synthesized.•Characterized by microanalysis, infrared, 1H and 13C NMR spectroscopy.•Antimicrobial, antibiofilm and antioxidant screening.

Four new platinum(IV) complexes C1–C4 of general formula [PtBr4(R2-S,S-eddv)], (R = ethyl, propyl, butyl and pentyl; S,S-eddv = (S,S)--ethylenediamine-N,N′-di-2-(3-methyl)butanoate) have been synthesized and characterized by microanalysis, infrared, 1H and 13C NMR spectroscopy. In vitro antimicrobial activity for these and [PtBr4(R2-S,S-eddp)] complexes (S,S-eddp = (S,S)-ethylenediamine-N,N′-di-2-propanoate) has been investigated. The antibacterial activity was tested against 16 strains of bacteria determining the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) using microdilution method. In general, platinum(IV) complexes manifested moderate activity against the Gram positive bacteria and low activity against the Gram negative bacteria. The complexes showed weak antioxidative properties tested by two methods (DPPH and reducing power assay).

Graphical abstractFour new platinum(IV) complexes have been obtained by reaction of potassium-hexabromidoplatinate(IV) with corresponding esters of (S,S)-ethylenediamine-N,N′-di-2-(3-methyl)butanoate. We investigated antimicrobial, antibiofilm and antioxidant activity of these and [PtBr4(R2-S,S-eddp)] complexes (S,S-eddp = (S,S)-ethylenediamine-N,N′-di-2-propanoate).Figure optionsDownload full-size imageDownload as PowerPoint slide