| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1308576 | Inorganica Chimica Acta | 2005 | 6 Pages |
Abstract
Many hydrolases found in nature have Zn(II) ions at their active site. Artificial hydrolases as alternatives for non-enzymatic hydrolysis were prepared by attaching Zn(II) cyclen complexes with an alcohol pendant to a polymeric support. These modified polymers showed a 104-fold enhanced intrinsic reactivity for the hydrolysis of activated phosphodiesters over the non-catalysed reaction in solution.
Graphical abstractZn(II) cyclen complexes with hydroxyl group were immobilised on a polymer and showed 104-fold rate enhancements for the hydrolysis of an activated phosphodiester compared to the non-catalysed reaction.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Thomas Walenzyk, Burkhard Koenig,