Organotin(IV) 4-methoxyphenylethanoates: Synthesis, spectroscopic characterization, X-ray structures and in vitro anticancer activity against human prostate cell lines (PC-3)

A series of organotin(IV) carboxylates, [Bu2SnL2] (1), [Et2SnL2] (2), [Me2SnL2] (3), [Bu3SnL]n(4), [Me6Sn2L2]n(5), [Ph3SnL]n(6) and [Oct2SnL2] (7), where L = O2CCH2C6H4OCH3-4, have been synthesized. These complexes have been characterized by elemental analysis, FT-IR and multinuclear NMR (1H, 13C and 119Sn). Based on spectroscopic results, the ligand appeared to coordinate to the Sn atom through COO moiety. Single crystal analysis has shown a bridging behavior of ligand in tributyl- and trimethyltin(IV) derivatives, and a chelating bidentate mode in diethyltin(IV) complex. Bioassay results have shown that these compounds have good antibacterial, antifungal and antitumor activity. The activity against prostate cancer cell lines (PC-3) decreased in the order 1 > 5 > 2 > 3 > 7.

Graphical abstractA series of Organotin(IV) complexes of 4-methoxyphenyl ethanoate have been synthesized, and characterized by elemental analysis FT-IR, multinuclear NMR (1H, 13C and 119Sn) and X-ray single crystal analysis. These complexes exhibited different structures in solution and solid state. Some of the complexes have shown significant antibacterial, antifungal and anticancer activity against prostate cell lines (PC-3).Figure optionsDownload full-size imageDownload as PowerPoint slide