| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1308846 | Inorganica Chimica Acta | 2009 | 6 Pages |
Abstract
The trans-platinum compound with formate leaving groups reacts with DNA in a manner similar to the parent dichlorides, producing significantly more DNA-DNA interstrand crosslinks than cisplatin. Use of the trans-carboxylate axis does not affect overall DNA binding profile compared to the chloride precursor, suggesting a similar biological profile.
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Sheena M. Aris, Kenneth M. Knott, Xiaohong Yang, David A. Gewirtz, Nicholas P. Farrell,