| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1308956 | Inorganica Chimica Acta | 2015 | 4 Pages |
•Non-toxic dark-stable and water-soluble carbonyl carrier.•Excellent biocompatibility and efficient cellular uptake.•Light-triggered carbon monoxide release characterized.•Photochemical modelling of heme oxygenase function.
Air- and water-stable rhenium carbonyl complexes are investigated as CO-carriers for studying the light-dependent release of small amounts of carbon monoxide under physiological conditions. The reported very low quantum yields are in a suitable range for studying potential applications as photochemical CO-releasing molecules (Photo-CORMs) without rapidly reaching cytotoxic levels of carbon monoxide. Preliminary results on bio-compatibility and selective uptake of the compounds into human colon carcinoma cells (Caco-2 cell line) are described.
Graphical abstractAir- and water-stable rhenium carbonyl complexes are investigated as CO-carriers for studying the light-dependent release of small amounts of carbon monoxide under physiological conditions. The reported very low quantum yields are in a suitable range for studying potential applications as photochemical CO-releasing molecules (Photo-CORMs) without rapidly reaching cytotoxic levels of carbon monoxide. Preliminary results on bio-compatibility and selective uptake of the compounds into human colon carcinoma cells (Caco-2 cell line) are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
