| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1309341 | Inorganica Chimica Acta | 2014 | 6 Pages |
Abstract
The cytotoxic activity of the new Pt(II) compounds in a panel of human tumor cell lines was juxtaposed to that of previously synthesized analogues. Cytotoxicity of the investigated complexes showed to be strongly dependent on their lipophilicity. The most prominent compound, featuring 3-benzyl-5-methyl-5-(4-pyridyl)hydantoin as carrier ligand, inhibits the viability of tested cells at low micromolar concentrations with IC50 values comparable to that of cisplatin. The cis- and trans-mixed am(m)ine complexes with general formula [PtL(NH3)Cl2] exhibited far less cytotoxicity than their analogue, featuring the same organic ligand (cis-[PtL2Cl2]).
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Adriana Bakalova, Rossen Buyukliev, Hristo Varbanov, Georgi Momekov,